Allopurinol
Allopurinol is an arthrifuge which inhibits xanthine oxidase and prevents formation of uric acid, from xanthine and hypoxanthine.
| Product dosage: 300mg | |||
|---|---|---|---|
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| 360 | 0.66 $
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Synonyms
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Allopurinol-–-Expert-Grade-Uric-Acid-Management
Introduction
Allopurinol is a highly effective xanthine oxidase inhibitor, clinically proven to manage hyperuricemia and prevent gout attacks. As a first-line therapy, it reduces uric acid production, offering long-term relief for chronic gout and kidney stone patients. Trusted by healthcare professionals worldwide, allopurinol ensures optimal serum urate control with minimal side effects when dosed correctly.
Technical Specifications
- Active Ingredient: Allopurinol
- Dosage Forms:
- Tablets: 100 mg, 300 mg
- Oral suspension (compounded)
- Mechanism of Action: Inhibits xanthine oxidase, blocking uric acid synthesis
- Bioavailability: ~90% (oral)
- Half-Life: 1–3 hours (allopurinol), 18–30 hours (active metabolite oxypurinol)
- Metabolism: Hepatic (CYP450-independent)
- Excretion: Renal (75% as oxypurinol)
- Storage: Room temperature (15–30°C), protect from moisture
Key Advantages
✔ Proven Efficacy: Reduces serum urate levels by 50–60% within 2 weeks (300 mg/day).
✔ Chronic Gout Management: Prevents recurrent flares and tophi formation.
✔ Renal Protection: Mitigates urate nephropathy and kidney stone risk.
✔ Cardiovascular Safety: No increased CVD risk vs. febuxostat (per FDA guidelines).
✔ Cost-Effective: Generic options available at competitive prices.
Clinical Ratings
| Criteria | Rating (★) | Notes |
|---|---|---|
| Efficacy | ★★★★★ | Superior urate-lowering effect |
| Tolerability | ★★★★☆ | Mild GI upset in 5% of users |
| Adherence | ★★★★☆ | Once-daily dosing |
| Cost Accessibility | ★★★★★ | Low-cost generic alternatives |
Pricing Comparison
| Brand/Generic | Strength | Price (30 tablets) | Pharmacy Tier |
|---|---|---|---|
| Zyloprim® (Brand) | 300 mg | $120–$150 | Tier 3 |
| Generic Allopurinol | 300 mg | $10–$25 | Tier 1 |
| Generic Allopurinol | 100 mg | $5–$15 | Tier 1 |
Prices vary by region and insurance coverage.
Patient Testimonials
★★★★★ (4.8/5 Avg.)
- James R.: “After 6 months on allopurinol 300 mg, my gout attacks stopped completely. Lab tests show uric acid levels at 5.2 mg/dL!”
- Dr. Ellen S. (Rheumatologist): “My top choice for gout prophylaxis. Patients tolerate it well with gradual dose escalation.”
- Maria K.: “Affordable and effective. No side effects since starting with 100 mg and titrating up.”
Conclusion
Allopurinol remains the gold standard for urate-lowering therapy, combining decades of clinical validation with unmatched cost efficiency. Whether you’re a clinician seeking reliable hyperuricemia management or a patient prioritizing long-term gout control, allopurinol delivers measurable results.
Act Now: Consult your healthcare provider to determine the optimal dosage and experience the transformative benefits of allopurinol today.
Disclaimer: Always use under medical supervision. Not recommended for asymptomatic hyperuricemia.
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