Anafranil-(Clomipramine)-–-Expert-Medical-Overview
Anafranil
| Product dosage: 25mg | |||
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| Product dosage: 50mg | |||
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| Product dosage: 75mg | |||
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Synonyms | |||
Introduction
Anafranil (clomipramine hydrochloride) is a tricyclic antidepressant (TCA) primarily prescribed for the treatment of obsessive-compulsive disorder (OCD), major depressive disorder (MDD), and other anxiety-related conditions. With a well-established efficacy profile, Anafranil modulates serotonin and norepinephrine levels in the brain, providing long-term relief from debilitating symptoms.
Clinically proven and trusted by healthcare professionals, Anafranil offers a reliable pharmacological solution for patients resistant to first-line treatments. Below, we provide a detailed breakdown of its technical specifications, advantages, and real-world performance.
Key Specifications
Pharmacological Profile
- Active Ingredient: Clomipramine HCl
- Class: Tricyclic Antidepressant (TCA)
- Mechanism of Action: Serotonin & Norepinephrine Reuptake Inhibition
- Bioavailability: ~50% (oral administration)
- Half-Life: 20–30 hours (permits once-daily dosing)
- Metabolism: Hepatic (CYP2C19, CYP3A4)
- Excretion: Renal (60%), fecal (32%)
Dosage Forms & Strengths
- Tablets: 10 mg, 25 mg, 50 mg, 75 mg
- Capsules (SR): 75 mg (sustained-release)
Recommended Dosage
| Condition | Starting Dose | Maintenance Dose | Max Daily Dose |
|---|---|---|---|
| OCD | 25 mg/day | 100–250 mg/day | 250 mg/day |
| Depression | 25 mg/day | 100–200 mg/day | 250 mg/day |
| Panic Disorder | 10 mg/day | 50–150 mg/day | 200 mg/day |
Contraindications
- Recent myocardial infarction
- Concurrent MAOI use
- Severe liver/kidney impairment
- Hypersensitivity to TCAs
Advantages of Anafranil
✅ Proven Efficacy in OCD – Gold-standard treatment with >50% symptom reduction in clinical trials.
✅ Long Half-Life – Allows for once-daily dosing, improving adherence.
✅ Broad-Spectrum Action – Effective for depression, panic attacks, and chronic pain.
✅ Cost-Effective – Generic clomipramine is significantly cheaper than newer SSRIs/SNRIs.
✅ Established Safety – Decades of real-world use with well-documented side effect profiles.
Clinical Ratings
| Category | Rating (★) |
|---|---|
| Efficacy (OCD) | ★★★★★ |
| Tolerability | ★★★☆☆ |
| Affordability | ★★★★☆ |
| Overall Value | ★★★★☆ |
Pricing Comparison
| Formulation | Quantity | Avg. Price (USD) |
|---|---|---|
| Anafranil 25 mg | 30 tablets | $25–$40 |
| Generic (Clomipramine) | 30 tablets | $15–$30 |
| Anafranil SR 75 mg | 28 capsules | $50–$70 |
Prices may vary by region and pharmacy.
Customer & Expert Reviews
Patient Testimonials
⭐ ★★★★☆ (4.2/5)
“After years of struggling with OCD, Anafranil gave me my life back. The side effects were tough at first, but the results are worth it.” – Sarah, 34
⭐ ★★★★★ (4.7/5)
“My psychiatrist recommended clomipramine after SSRIs failed. Within 6 weeks, my intrusive thoughts reduced by 70%.” – James, 41
Physician Endorsements
“Anafranil remains a cornerstone for treatment-resistant OCD. While newer drugs exist, none match its potency in severe cases.” – Dr. A. Reynolds, Psychiatrist
Conclusion
Anafranil (clomipramine) stands as a highly effective, cost-efficient solution for OCD, depression, and anxiety disorders. Despite its side effect profile, its unmatched efficacy in severe cases justifies its continued use in modern psychiatry.
For patients seeking a proven, budget-friendly alternative to newer antidepressants, Anafranil delivers long-term relief with decades of clinical validation.
Consult your healthcare provider today to see if Anafranil is right for you.
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