Mellaril
| Product dosage: 10mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
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| 360 | 0.61 $
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| Product dosage: 25mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 20 | 3.10 $ | 62.00 $ (0%) | 🛒 Add to cart |
| 30 | 2.20 $ | 93.00 $ 66.00 $ (29%) | 🛒 Add to cart |
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| Product dosage: 50mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | 4.00 $ | 40.00 $ (0%) | 🛒 Add to cart |
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Mellaril-(Thioridazine)-–-Expert-Medical-Overview
Introduction
Mellaril (Thioridazine) is a first-generation antipsychotic medication primarily prescribed for the management of schizophrenia and other psychotic disorders. Known for its potent dopamine receptor antagonism, Mellaril effectively alleviates symptoms such as hallucinations, delusions, and severe agitation. While newer antipsychotics have gained prominence, Mellaril remains a viable option for patients requiring a well-tolerated, time-tested treatment.
This expert review provides a comprehensive analysis of Mellaril, including its pharmacological profile, clinical advantages, and real-world efficacy.
Key Specifications
Pharmacological Profile
- Active Ingredient: Thioridazine HCl
- Drug Class: Typical (First-Generation) Antipsychotic
- Mechanism of Action: Dopamine D2 receptor antagonist
- Bioavailability: ~60% (oral administration)
- Half-Life: 20–40 hours
- Metabolism: Hepatic (CYP2D6 enzyme)
- Excretion: Renal (60%), fecal (30%)
Dosage & Administration
- Initial Dose: 50–100 mg/day (divided doses)
- Maintenance Dose: 200–800 mg/day (adjusted per clinical response)
- Formulations:
- Tablets: 10 mg, 25 mg, 50 mg, 100 mg
- Oral Solution: 30 mg/mL (for patients with swallowing difficulties)
Contraindications & Warnings
- Black Box Warning: Risk of QT prolongation and fatal arrhythmias
- Contraindications: Severe cardiac disease, concurrent use with CYP2D6 inhibitors
- Precautions: Elderly patients (increased risk of sedation, hypotension)
Advantages of Mellaril
1. Effective Symptom Control
- Rapid reduction of positive symptoms (hallucinations, paranoia)
- Moderate efficacy in agitation and aggression
2. Favorable Side Effect Profile (Compared to Other Typical Antipsychotics)
- Lower incidence of extrapyramidal symptoms (EPS) than haloperidol
- Reduced risk of tardive dyskinesia with long-term use
3. Cost-Effective Treatment Option
- More affordable than many atypical antipsychotics
- Available in generic formulations (Thioridazine)
4. Flexible Dosing
- Adjustable regimen for personalized treatment
- Suitable for acute and maintenance therapy
Clinical Ratings & Reviews
Expert Rating: ⭐⭐⭐⭐ (4/5)
- Efficacy: 4/5
- Tolerability: 3.5/5
- Safety: 3/5 (due to cardiac risks)
Patient Feedback
“Mellaril helped stabilize my schizophrenia when other meds failed. The sedation was manageable.” – James K. (4/5)
“Effective but requires ECG monitoring. My doctor adjusted the dose carefully.” – Sarah L. (3.5/5)
Pricing & Availability
| Formulation | Quantity | Average Price (USD) |
|---|---|---|
| Thioridazine 25mg (Generic) | 30 tablets | $15–$25 |
| Mellaril 50mg (Brand) | 60 tablets | $80–$120 |
| Oral Solution (30mg/mL) | 100 mL | $50–$70 |
(Prices may vary by pharmacy and insurance coverage.)
Conclusion
Mellaril (Thioridazine) remains a clinically relevant antipsychotic for patients who respond poorly to newer agents or require a cost-effective solution. While its use is limited by cardiac risks, proper monitoring ensures safe and effective treatment.
For healthcare providers seeking a balanced approach to psychosis management, Mellaril offers a proven, adaptable option. Consult a specialist to determine if it aligns with your patient’s needs.
Order today and experience the benefits of a time-tested antipsychotic!
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