Methotrexate
| Product dosage: 10mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | 4.47 $ | 134.00 $ (0%) | 🛒 Add to cart |
| 60 | 4.02 $ | 268.00 $ 241.00 $ (10%) | 🛒 Add to cart |
| 90 | 3.87 $ | 402.00 $ 348.00 $ (13%) | 🛒 Add to cart |
| 120 | 3.79 $ | 536.00 $ 455.00 $ (15%) | 🛒 Add to cart |
| 180 | 3.71 $
Best per pill | 804.00 $ 668.00 $ (17%) | 🛒 Add to cart |
| Product dosage: 2.5mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | 1.93 $ | 58.00 $ (0%) | 🛒 Add to cart |
| 60 | 1.57 $ | 116.00 $ 94.00 $ (19%) | 🛒 Add to cart |
| 90 | 1.44 $ | 174.00 $ 130.00 $ (25%) | 🛒 Add to cart |
| 120 | 1.38 $ | 232.00 $ 165.00 $ (29%) | 🛒 Add to cart |
| 180 | 1.32 $ | 348.00 $ 237.00 $ (32%) | 🛒 Add to cart |
| 270 | 1.27 $ | 522.00 $ 344.00 $ (34%) | 🛒 Add to cart |
| 360 | 1.25 $
Best per pill | 696.00 $ 451.00 $ (35%) | 🛒 Add to cart |
| Product dosage: 5mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | 3.00 $ | 90.00 $ (0%) | 🛒 Add to cart |
| 60 | 2.77 $ | 180.00 $ 166.00 $ (8%) | 🛒 Add to cart |
| 90 | 2.68 $ | 270.00 $ 241.00 $ (11%) | 🛒 Add to cart |
| 120 | 2.64 $ | 360.00 $ 317.00 $ (12%) | 🛒 Add to cart |
| 180 | 2.60 $ | 540.00 $ 468.00 $ (13%) | 🛒 Add to cart |
| 270 | 2.57 $
Best per pill | 810.00 $ 694.00 $ (14%) | 🛒 Add to cart |
Methotrexate--A-Potent-Antimetabolite-for-Targeted
Methotrexate is a highly effective antimetabolite and antifolate agent widely used in oncology, rheumatology, and dermatology. As a competitive inhibitor of dihydrofolate reductase (DHFR), it disrupts DNA synthesis, making it indispensable in the treatment of malignancies (e.g., leukemia, lymphoma) and autoimmune conditions (e.g., rheumatoid arthritis, psoriasis). Its proven efficacy, safety profile, and cost-effectiveness make it a first-line therapeutic choice.
Technical Specifications
- Chemical Name: (2S)-2-[(4-{(2,4-Diaminopteridin-6-yl)methylamino}benzoyl)amino]pentanedioic acid
- Molecular Formula: C₂₀H₂₂N₈O₅
- Dosage Forms:
- Tablets (2.5 mg, 5 mg, 10 mg)
- Injectable solutions (25 mg/mL, 50 mg/mL)
- Mechanism of Action: Inhibits DHFR, depleting tetrahydrofolate and impairing thymidine/purine synthesis.
- Half-life: 3–10 hours (dose-dependent).
- Storage: 20–25°C, protect from light.
- Bioavailability: ~60% (oral), 100% (IV/IM).
Key Advantages of Methotrexate
✅ Broad Therapeutic Spectrum
- FDA-approved for leukemia, RA, psoriasis, and ectopic pregnancy.
- Off-label uses in Crohn’s disease and lupus.
✅ Cost-Effective
- Significantly cheaper than biologics (e.g., TNF-α inhibitors).
✅ Flexible Administration
- Oral, IV, IM, or intrathecal routes for tailored therapy.
✅ Proven Long-Term Safety
- Decades of clinical use with well-managed side effects (e.g., leucovorin rescue).
✅ High Efficacy
- Remission rates of 60–80% in RA when combined with DMARDs.
Performance Rating
| Category | Rating (★/5) |
|---|---|
| Efficacy | ★★★★★ |
| Safety | ★★★★☆ |
| Affordability | ★★★★★ |
| Convenience | ★★★★☆ |
| Overall | ★★★★☆ |
Note: 1★ = Poor, 5★ = Excellent
Pricing Table
| Formulation | Dosage | Price Range (USD) |
|---|---|---|
| Methotrexate Tablets | 2.5 mg (30 tabs) | $15 – $30 |
| Methotrexate Tablets | 10 mg (30 tabs) | $25 – $50 |
| Methotrexate Injection | 50 mg/2 mL vial | $40 – $80 |
| Methotrexate Injection | 1 g/10 mL vial | $150 – $300 |
Prices vary by supplier and region. Bulk discounts available.
Customer Testimonials
Dr. Emily R., Oncologist (★★★★★)
“Methotrexate remains the backbone of ALL induction therapy. Its predictable pharmacokinetics and low cost make it irreplaceable.”
Sarah L., Rheumatoid Arthritis Patient (★★★★☆)
“After failing NSAIDs, methotrexate gave me my life back. Minor nausea, but worth it.”
Clinical Pharmacist (★★★☆☆)
“Requires careful monitoring (CBC, LFTs), but unmatched for cost-benefit ratio.”
Conclusion: Why Choose Methotrexate?
Methotrexate is a gold-standard therapy combining affordability, versatility, and robust clinical evidence. Whether managing aggressive malignancies or chronic inflammation, its balanced risk-benefit profile ensures optimal outcomes.
🔹 For Healthcare Providers: Stock up on this essential agent to enhance treatment protocols.
🔹 For Patients: Consult your physician to see if methotrexate fits your therapeutic plan.
Order today and leverage decades of trusted efficacy!
Disclaimer: Prescription required. Not for self-administration. Monitor for myelosuppression/hepatotoxicity.
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