Prasugrel-–-Advanced-Antiplatelet-Therapy-for-Card

Prasugrel

Prasugrel

Prasugrel is used in people who’ve had a balloon angioplasty to open blocked arteries after having a heart attack or severe chest pain. Prasugrel may help lower your risk of having another heart attack or stroke. Also used for the prevention of thrombotic complications in patients with acute coronary syndrome (ACS) and for prevention of stent thrombosis in acute coronary syndromes.
Product dosage: 10 mg
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Synonyms

Prasugrel is a potent P2Y12 adenosine diphosphate (ADP) receptor antagonist used to prevent thrombotic cardiovascular events in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). As a third-generation thienopyridine, it offers superior platelet inhibition compared to older agents, reducing the risk of stent thrombosis, myocardial infarction (MI), and stroke.


Key Technical Specifications

  • Active Ingredient: Prasugrel hydrochloride
  • Dosage Forms: 5 mg, 10 mg film-coated tablets
  • Mechanism of Action: Irreversible P2Y12 receptor inhibition
  • Bioavailability: ≥79% (rapid absorption)
  • Peak Plasma Concentration: ~30 minutes
  • Half-Life: ~7 hours (active metabolite)
  • Metabolism: Hepatic (CYP3A4, CYP2B6)
  • Excretion: Renal (68%), fecal (27%)
  • Storage Conditions: Below 30°C (86°F), protect from moisture

Advantages of Prasugrel

Superior Antiplatelet Efficacy – Faster and more consistent platelet inhibition than clopidogrel.
Reduced Thrombotic Events – Proven to lower rates of stent thrombosis and recurrent MI.
Optimal for High-Risk Patients – Recommended for diabetic patients and those with prior stent thrombosis.
Minimal Drug-Drug Interactions – Less affected by CYP2C19 polymorphisms compared to clopidogrel.
Convenient Dosing – Once-daily administration improves compliance.


Clinical Performance & Ratings

ParameterRating (★/5)Remarks
Efficacy★★★★★Superior to clopidogrel in TRITON-TIMI 38 trial
Safety★★★★☆Higher bleeding risk vs. clopidogrel (managed with proper dosing)
Patient Adherence★★★★★Simple dosing regimen
Cost-Effectiveness★★★★☆Justified by reduced cardiovascular events

Pricing Comparison (Approximate)

Brand/GenericDosagePrice per Unit (USD)
Effient (Brand)10 mg$8.50 - $10.00
Generic Prasugrel10 mg$4.00 - $6.50
Clopidogrel (Generic)75 mg$1.50 - $3.00

Prices may vary by region and pharmacy.


Customer & Physician Reviews

Dr. Alan K., Cardiologist (★★★★★)

“Prasugrel is my go-to for high-risk PCI patients. The rapid onset of action and consistent platelet suppression make it invaluable in preventing stent thrombosis.”

Patient Review (★★★★☆)

“Switched from clopidogrel after a minor heart attack. No issues so far, and my cardiologist says my platelet tests look great!”

Hospital Pharmacist (★★★★★)

“The generic version has made prasugrel more accessible without compromising efficacy. A game-changer in ACS management.”


Conclusion: Why Choose Prasugrel?

Prasugrel stands as a first-line antiplatelet agent for ACS patients undergoing PCI, offering unmatched efficacy in preventing life-threatening thrombotic events. While it carries a slightly higher bleeding risk, proper patient selection and dosing mitigate this concern.

For cardiologists, interventionalists, and pharmacists, prasugrel represents a cost-effective, high-performance alternative to older therapies. Its proven clinical benefits make it a must-have in modern cardiovascular care.

🔹 Order now and enhance your formulary with a superior antiplatelet solution!

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