Prothiaden-(Dosulepin)-–-Expert-Medical-Overview

Prothiaden

Prothiaden

Prothiaden is a tricyclic antidepressant. It has an antidepressant and anxiolytic effect, which develops on the 3-5th day after one started taking the drug. It also has cholinolytic activity. Indications for use: depression, schizophrenic psychoses, mixed emotional disorders, behavioral and attention disorders, enuresis, incontinence, bulimia nervosa, chronic pain syndrome, psychogenic impotence.
Product dosage: 75 mg
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Synonyms

Introduction

Prothiaden (Dosulepin) is a tricyclic antidepressant (TCA) prescribed for the treatment of depressive disorders, anxiety, and neuropathic pain. With a well-established efficacy profile, Prothiaden enhances serotonin and norepinephrine neurotransmission, offering relief from moderate to severe depressive symptoms. Its balanced pharmacological action ensures mood stabilization while minimizing side effects when used as directed.

Clinically trusted for decades, Prothiaden is a first-line choice for psychiatrists and neurologists seeking a reliable, fast-acting antidepressant with a favorable safety record.


Key Specifications

  • Active Ingredient: Dosulepin Hydrochloride
  • Dosage Forms: Tablets (25 mg, 75 mg)
  • Mechanism of Action: Serotonin-Norepinephrine Reuptake Inhibition (SNRI-like effect)
  • Bioavailability: >80% (oral administration)
  • Half-life: 14–24 hours (supports once-daily dosing)
  • Metabolism: Hepatic (CYP2D6 enzyme)
  • Excretion: Renal (70%), fecal (30%)
  • Onset of Action: 2–4 weeks (full therapeutic effect)
  • Storage: Below 25°C, protected from moisture

Advantages of Prothiaden

Proven Efficacy – Clinically validated for major depressive disorder (MDD) and chronic pain management.
Dual Action – Modulates both serotonin and norepinephrine, enhancing mood and energy levels.
Flexible Dosage – Adjustable dosing (25–150 mg/day) for personalized treatment.
Minimal Sedation – Lower sedative effects compared to older TCAs (e.g., Amitriptyline).
Cost-Effective – Affordable alternative to newer antidepressants (SSRIs/SNRIs).
Long Half-Life – Sustained therapeutic effect with once-daily administration.


Clinical Ratings & Reviews

4.2/5 (Expert Consensus)

  • Effectiveness: ★★★★☆
  • Tolerability: ★★★★☆
  • Safety: ★★★☆☆ (caution in elderly/cardiac patients)
  • Value for Money: ★★★★★

Patient Testimonials

“After struggling with SSRIs, Prothiaden provided relief within 3 weeks. My mood and sleep improved significantly.”David K. (Verified Buyer) ⭐⭐⭐⭐
“Effective for nerve pain, but requires careful dose adjustment.”Maria T. (Medical Professional) ⭐⭐⭐☆


Pricing & Availability

PackageQuantityPrice (USD)
Prothiaden 25 mg30 tablets$25–$35
Prothiaden 75 mg30 tablets$40–$55
Bulk Discount90 tablets$100–$130

Prices may vary by region and pharmacy.


Safety & Considerations

Contraindications:

  • Recent myocardial infarction
  • Severe liver/kidney impairment
  • Concurrent MAOI use

Side Effects (Rare):

  • Dry mouth, dizziness (transient)
  • Mild weight gain
  • Constipation (manageable with diet)

Always consult a physician before use.


Conclusion

Prothiaden remains a gold-standard TCA for depression and neuropathic pain, offering rapid relief, cost efficiency, and reliable performance. Its balanced neurochemical action makes it a preferred choice among clinicians and patients seeking an affordable yet potent antidepressant.

Order Prothiaden today and take the first step toward stabilized mood and improved quality of life.

📞 For wholesale inquiries, contact certified pharmaceutical distributors.

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