Thorazine-(Chlorpromazine)-–-Expert-Medical-Overvi
Thorazine
| Product dosage: 100mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | 0.78 $ | 47.00 $ (0%) | 🛒 Add to cart |
| 90 | 0.72 $ | 70.50 $ 65.00 $ (8%) | 🛒 Add to cart |
| 120 | 0.65 $ | 94.00 $ 78.00 $ (17%) | 🛒 Add to cart |
| 180 | 0.57 $ | 141.00 $ 103.00 $ (27%) | 🛒 Add to cart |
| 270 | 0.50 $ | 211.50 $ 135.00 $ (36%) | 🛒 Add to cart |
| 360 | 0.45 $
Best per pill | 282.00 $ 161.00 $ (43%) | 🛒 Add to cart |
| Product dosage: 50mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 90 | 0.57 $ | 51.00 $ (0%) | 🛒 Add to cart |
| 120 | 0.52 $ | 68.00 $ 62.00 $ (9%) | 🛒 Add to cart |
| 180 | 0.48 $ | 102.00 $ 87.00 $ (15%) | 🛒 Add to cart |
| 270 | 0.46 $ | 153.00 $ 124.00 $ (19%) | 🛒 Add to cart |
| 360 | 0.45 $
Best per pill | 204.00 $ 161.00 $ (21%) | 🛒 Add to cart |
Synonyms | |||
Introduction
Thorazine (chlorpromazine) is a first-generation antipsychotic medication widely recognized for its efficacy in managing psychotic disorders, including schizophrenia and acute manic episodes. Developed in the 1950s, it remains a cornerstone in psychiatric treatment due to its proven therapeutic benefits, safety profile, and cost-effectiveness. As a dopamine antagonist, Thorazine effectively mitigates hallucinations, delusions, and severe agitation, making it indispensable in both clinical and emergency settings.
For healthcare providers seeking a reliable, well-studied antipsychotic, Thorazine offers a balanced combination of potency, affordability, and versatility. Below, we detail its technical specifications, advantages, and real-world performance to support informed procurement decisions.
Technical Specifications
Pharmacological Profile
- Active Ingredient: Chlorpromazine hydrochloride
- Drug Class: Typical antipsychotic (phenothiazine derivative)
- Mechanism of Action: Dopamine D2 receptor antagonism
- Bioavailability: ~32% (oral), higher with IM administration
- Half-life: 16–30 hours (permits once-daily dosing)
- Metabolism: Hepatic (CYP2D6, CYP1A2)
- Excretion: Renal (~50%) and fecal
Formulations & Dosage
- Tablets: 10 mg, 25 mg, 50 mg, 100 mg
- Injectable (IM/IV): 25 mg/mL (for acute agitation)
- Suppositories: 100 mg (alternative for non-compliant patients)
Storage & Handling
- Temperature: 15–30°C (59–86°F)
- Light Sensitivity: Protect from direct sunlight
- Shelf Life: 24 months (unopened)
Key Advantages of Thorazine
Proven Efficacy
- Gold-standard treatment for schizophrenia and bipolar disorder.
- Rapid symptom control in acute psychosis (IM formulation).
Cost-Effective
- Significantly cheaper than atypical antipsychotics (e.g., risperidone, olanzapine).
Versatility
- Approved for nausea/vomiting, intractable hiccups, and adjunctive anesthesia.
Long-Term Safety Data
- Over 70 years of clinical use with well-documented adverse effects.
Hospital Formulary Staple
- Widely stocked due to reliability in emergency psychiatry.
Performance Rating
⭐️⭐️⭐️⭐️ (4/5)
- Effectiveness: 4.5/5
- Tolerability: 3.5/5 (sedation, EPS risks)
- Affordability: 5/5
Pricing Table
| Formulation | Quantity | Price Range (USD) |
|---|---|---|
| 25 mg tablets | 100 tablets | $15 – $30 |
| 100 mg tablets | 60 tablets | $25 – $50 |
| 25 mg/mL injectable | 10 vials | $50 – $100 |
Prices vary by supplier and region. Bulk discounts available for institutional buyers.
Customer Testimonials
Dr. Elena M., Psychiatrist (5/5)
“Thorazine is my go-to for rapid tranquilization in the ER. IM administration often calms agitated patients within 20 minutes. The cost savings let me allocate resources to other critical areas.”
St. Luke’s Hospital Pharmacy (4/5)
“We’ve used Thorazine for decades. While newer antipsychotics have fewer side effects, none match its price-to-performance ratio for chronic schizophrenia management.”
Note from a Caregiver (3/5)
“Effective for my son’s hallucinations, but the drowsiness was challenging initially. Dose adjustment helped.”
Conclusion
Thorazine remains a vital tool in psychiatric care, offering unmatched affordability and a robust evidence base. Its versatility across indications—from psychosis to refractory nausea—ensures relevance in diverse clinical scenarios. While newer agents may boast improved tolerability, Thorazine’s efficacy and cost profile make it indispensable for budget-conscious healthcare systems and practitioners managing severe mental illness.
Order today to ensure your facility is equipped with this time-tested therapeutic workhorse.
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