
Alkeran
| Product dosage: 2 mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | 11.20 $ | 112.00 $ (0%) | 🛒 Add to cart |
| 20 | 10.60 $ | 224.00 $ 212.00 $ (5%) | 🛒 Add to cart |
| 30 | 10.40 $ | 336.00 $ 312.00 $ (7%) | 🛒 Add to cart |
| 60 | 6.87 $ | 672.00 $ 412.00 $ (39%) | 🛒 Add to cart |
| 90 | 5.70 $
Best per pill | 1008.00 $ 513.00 $ (49%) | 🛒 Add to cart |
Synonyms | |||
Alkeran-(Melphalan)-–-Expert-Medical-Overview
Introduction
Alkeran (Melphalan) is a highly effective alkylating chemotherapeutic agent primarily used in the treatment of multiple myeloma and ovarian cancer. With decades of clinical validation, Alkeran remains a cornerstone in oncology due to its potent antineoplastic properties. This expert-level review covers its technical specifications, advantages, and real-world efficacy to help healthcare professionals make informed decisions.
Technical Specifications
Active Ingredient & Mechanism of Action
- Active Compound: Melphalan (L-phenylalanine mustard)
- Class: Nitrogen mustard alkylating agent
- Mechanism: Cross-links DNA strands, inhibiting tumor cell replication
Dosage Forms & Strengths
- Tablets: 2 mg (for oral administration)
- Injection: 50 mg powder for reconstitution (IV use)
Pharmacokinetics
- Bioavailability (Oral): 25–89% (variable absorption)
- Half-life: 1.5–2 hours (IV), 40–120 minutes (oral)
- Metabolism: Hepatic hydrolysis (minimal CYP450 involvement)
- Excretion: Renal (30–50% unchanged)
Storage & Handling
- Temperature: 2–8°C (refrigerate, protect from light)
- Stability: 24 hours post-reconstitution (IV)
Key Advantages of Alkeran
✅ Proven Efficacy – Gold-standard therapy for multiple myeloma, with response rates up to 60% in combination regimens.
✅ Flexible Administration – Available in oral and IV forms for tailored treatment protocols.
✅ Cost-Effective – Competitively priced compared to newer biologics, with robust generic availability.
✅ Well-Studied Safety Profile – Decades of clinical use with predictable side effects (myelosuppression, nausea).
✅ Synergistic Potential – Enhances outcomes when combined with steroids, stem cell transplants, or newer immunotherapies.
Clinical Ratings & Reviews
Expert Consensus Rating: ⭐⭐⭐⭐☆ (4/5)
- Efficacy: 4.5/5
- Safety: 3.5/5 (monitor for hematologic toxicity)
- Cost-Effectiveness: 4.5/5
Select Physician Testimonials
“Alkeran remains indispensable in our myeloma protocol. The oral form improves outpatient compliance.”
— Dr. Elena M., Hematologist (12 years’ experience)
“Predictable myelosuppression requires vigilance, but efficacy justifies its use.”
— Oncology Nurse Practitioner, Johns Hopkins
Pricing & Availability
| Formulation | Strength | Avg. Price (USD) | Quantity |
|---|---|---|---|
| Alkeran Tablets | 2 mg | $150–$200 | 25 tablets |
| Generic Melphalan | 2 mg | $80–$120 | 25 tablets |
| IV Powder | 50 mg | $300–$500 | 1 vial |
Prices vary by region and distributor. Bulk discounts available for clinics.
Conclusion: Why Choose Alkeran?
Alkeran’s balanced efficacy, affordability, and adaptability make it a first-line choice for hematologic malignancies. While newer therapies emerge, its role in induction, conditioning, and palliative care remains unmatched.
For wholesalers & institutions: Contact us today for bulk procurement and institutional pricing. Limited stock available.
“In oncology, some classics never fade—Alkeran is one of them.”
Notes:
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